Molecular hydrogen improves obesity and diabetes…and stimulating energy metabolism in mice
Naomi Kamimura et al.
Recent extensive studies have revealed that molecular hydrogen H2 has great potential for improving oxidative stress-related diseases by inhaling H2 gas, injecting saline with dissolved H2, or drinking hydrogen rich water; however, little is known about the dynamic movement of H2 in a body.
First, we show that liver glycogen accumulates H2 after oral administration of Hydrogen-rich water, explaining why consumption of even a small amount of hydrogen over a short span time efficiently improves various disease models.
The benefits of drinking hydrogen water ad libitum, on type 2 diabetes was investigated, using db/db obesity mice. Drinking Hydrogen water reduced oxidative stress in the liver, and significantly alleviated fatty liver in db/db mice as well as high fat-diet-induced fatty liver in wild-type mice.
Long-term drinking of hydrogen rich water significantly controlled fat and body weights…
Drinking Hydrogen water also decreased levels of plasma glucose, insulin, and triglyceride, the effect of which on hyperglycemia was similar to diet restriction!!!.
To examine how drinking Hydrogen rich water improves obesity and metabolic parameters at the molecular level, gene-expression profiles were examined.
The findings were that, indeed, hydrogen (H2) stimulated energy metabolism as measured by oxygen consumption. The present results suggest the potential benefit of Hydrogen (H2) in improving obesity, diabetes, and metabolic syndrome.
DDW relating to weight loss, obesity protection and increased metabolism during periods of unhealthy diet or obesity
“Deuterium-Depleted Water as Adjuvant Therapeutic Agent for Treatment of Diet-Induced Obesity in Rats”
Tetiana Halenova et al.
This study shows a potential application of deuterium-depleted water (DDW)
for the prevention and adjuvant treatment of obesity in rats.
We tested the hypothesis that DDW can alleviate diet-induced obesity (DIO) and its associated metabolic impairments. Rats fed a high-fat diet had an increased body weight index (BWI), glucose concentration, and level of certain proinflammatory cytokines; decreased levels of insulin in the serum; decreased tryptophan and serotonin in the brain, and a decreased concentration of some heavy metals in the liver.
Drinking DDW at a concentration of 10 ppm deuterium/protium (D/H) ad libitum for 3 weeks restored the BWI, glucose (serum), tryptophan (brain), and serotonin (brain) levels and concentration of Zn in the liver in the DIO animals to those of the controls.
The levels of proinflammatory cytokines (IL-1β, IL-6, IFNγ) and anti-inflammatory TNFα were decreased in DIO rats, while anti-inflammatory cytokine (IL-4, IL-10) levels remained at the control levels, which is indicative of a pathophysiological syndrome. In contrast, in groups of rats treated with DDW, a significant increase in anti-inflammatory (IL-4, IL-10) and proinflammatory cytokines (IFNγ) was observed.
This finding indicates a reduction in systemic inflammation in obese animals treated with DDW.
Similarly, the high-fat diet caused an increased level of oxidative stress products, which was accompanied by decreased activity of both superoxide dismutase and catalase, whereas the administration of DDW decreased the level of oxidative stress and enhanced antioxidant enzyme activities.
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