Hydrogen protects rats from dermatitis caused by local radiation.
Mei, K., et al.
Hydrogen significantly reduced the severity of dermatitis, accelerated tissue recovery, and reduced the extent of radiation-induced weight loss in rats after a single dose of 15 or 20 Gy but not 25 Gy of radiation. Hydrogen was also protective from cumulative doses of 30 Gy delivered in three fractions, respectively. Hydrogen also protect HaCaT cells from radiation-induced injury, it could significantly inhibit ionizing injury.
Long-term treatment of hydrogen-rich saline abates testicular oxidative stress induced by nicotine in mice.
Li, S., et al.
It was found that vitamin C and vitamin E attenuated serum oxidative level, but did not lower testicular oxidative levels in mice subjected to chronic nicotine treatment, and did not improve the male reproductive damage and apoptosis induced by nicotine. Different from normal antioxidants, vitamin C and vitamin E, hydrogen-rich saline (hydrogen rich water) abated oxidative stress in testis, and protected against nicotine-induced male reproductive damages.
Neuroprotective effect of hydrogen-rich saline in acute carbon monoxide poisoning.
Shen, M.H., et al.
“…hydrogen rich saline may be clinically useful against acute CO poisoning, possibly via reducing (Free Radicals) ROS level, up-regulating endogenous antioxidative enzymes, suppressed caspase enzyme activity, upregulated ratio of Bcl‐2 and Bax expression, and abated apoptosis.
Molecular hydrogen and radiation protection.
Chuai, Y., et al. Free Radical Research, 2012. 46(9): p. 1061-7.
Molecular hydrogen (hydrogen water) acts as a therapeutic antioxidant by selectively reducing hydroxyl radicals (•OH) and peroxynitrite (ONOO-). It has been well-known that ionising radiation (IR) causes oxidative damage and consequent apoptosis (cell-death) mainly due to the production of •OH that follows radiolysis of H(2)O. Our department reported the protective effect of H(2) in irradiated cells and mice for the first time, and this effect is well repeated by us and another laboratory in different experimental animal models.
Comment: This may show to be a relevant study in other radiation models, such as in strong radiation fields generated by microwave or mobile radiation in the 5 GHz range, as currently debated internationally.
DEUTERIUM DEPLETED WATER (DDW)
Protection against free radicals (ROS) caused by toxins, heavy metals and radiation
“Research Concerning the Radioprotective and Immunostimulating Effects of Deuterium-Depleted Water”
W. Bild et al.
Deuterium-depleted water was able to protect mice from the harmful effects of critical amounts of radioactive radiation and increased their chances of survival substantially, from only 25% without DDW, to 61% survival with DDW.
“Influence of Deuterium Depleted Water on the Organism of Laboratory Animals in Various Functional Conditions of Nonspecific Protective Systems”
A. B. Lisitsyn et al.
The impact of this water on biochemical indicators (AST, ALT, alkaline phosphatase, creatinine, bilirubin) and dynamics in body weight of laboratory animals within 42 days is established. As a result of studies the possibility of the preventive use of deuterium depleted water for correction of metabolic processes is shown in various conditions of the functional system of the body’s detoxification.
The radioprotective effect of deuterium depleted water and polyphenols
Gabriel C. Corneanu et al. in Environmental Engineering and Management Journal.
Study in mice confirmed the liver protective effect of deuterium depleted water in combination with polyphenol extract.
“Submolecular regulation of cell transformation by deuterium depleting water exchange reactions in the tricarboxylic acid substrate cycle”
László Boros et al.
Deuterium depleted light water is able to protect DNA from radiation damage and the authors here establish a ling between mitochondrial deuterium load and dietary factors and cellular deuterium detoxification mechanisms…
Overview: Fact-box found in this study states the following
What is known about this topic?
- Deuterium depletion seems to protect cells by maintaining strong hydrogen bond networks.
- Deuterium depleted water inhibits cancer cell growth as well as tumor progression.
- Hydratases and isomerases of the TCA and pentose-cycles transfer deuterium depleted mitochondrial matrix water to intermediates and subsequently stabilize DNA.
- Deuterium depletion protects cells from exceptional deuterium substitution effects in hydrogen bridging biological networks.
- Ketogenic substrates, water and drugs promote deuterium depletion of mitochondrial metabolic matrix water, offering a means to prevent tumor cell growth.
What this study adds?
- Defective mitochondrial functions, molecular oxygen deprivation and increased glycolysis induce cellular transformations which can cause a shift in 2H/1H ratio in mammalian cells.
- Switching from a ketogenic to high sugar diet interferes with the deuterium depleting action of mitochondria serving as a potential oncogenic initiator.
- The results of this analysis contain new data relevant to cancer prevention and treatment.
“The naturally occurring isotope of hydrogen (1H), deuterium (2H), could have an important biological role. Deuterium depleted water delays tumor progression in mice, dogs, cats and humans. Hydratase enzymes of the tricarboxylic acid (TCA) cycle control cell growth and deplete deuterium from redox cofactors, fatty acids and DNA, which undergo hydride ion and hydrogen atom transfer reactions. A model is proposed that emphasizes the terminal complex of mitochondrial electron transport chain reducing molecular oxygen to deuterium depleted water (DDW); this affects gluconeogenesis as well as fatty acid oxidation. In the former, the DDW is thought to diminish the deuteration of sugar-phosphates in the DNA backbone, helping to preserve stability of hydrogen bond networks, possibly protecting against aneuploidy and resisting strand breaks, occurring upon exposure to radiation and certain anticancer chemotherapeutics. DDW is proposed here to link cancer prevention and treatment using natural ketogenic diets, low deuterium drinking water…”
Cadmium pollution and associated cadmium toxicity. This study confirms the protective effect of Deuterium Depleted Water (DDW) in a rats.
Mihaela Doina Petcu et al.
“Variation of the Deuterium concentration in rats’ blood after deuterium depleted water administration and intoxication with Cadmium”
Protection liver against acetaminophen toxicity:
“In conclusion, our results revealed that DDW and DDW+ E.O have a potent hepatoprotective effect upon acetaminophen toxicity in rats by reducing the formation and detoxification of the active intermediate APAP metabolite”
Repair of damage caused by free radicals in the liver
DDW combined with linseeds
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