BRAIN FUNCTION and BRAIN HEALTH STUDIES

HYDROGEN-RICH WATER STUDIES

DEUTERIUM DEPLETED WATER STUDIES (DDW)

HYDROGEN gas and water relating to brain function

Molecular hydrogen is protective against 6-hydroxydopamine-induced nigrostriatal degeneration in a rat model of Parkinson’s disease“.
Yuan Fu et al.
Hydrogen-rich water is a selective antioxidant that reduces hydroxyl radicals, but not the other reactive oxygen and nitrogen species… In Parkinson’s disease, mitochondrial dysfunction and the associated oxidative stress, are major causes of dopaminergic cell loss… “Our studies suggest that hydrogen water is likely able to retard the development and progression of Parkinson’s disease”.

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Hydrogen is neuroprotective against surgically induced brain injury“.
Jan M. Eckermann et al. Medical Gas Research, 2011. 1(1): p. 7.
Neurosurgical operations cause unavoidable damage to healthy brain tissues. Direct surgical injury as well as surgically induced oxidative stress contributes to the subsequent formation of brain edema. Therefore, we tested the neuroprotective effects of hydrogen (H2) in rats.

Hydrogen (2.9%) administered concurrently with surgery significantly decreased the formation of cerebral edema (p = 0.028) and improved neurobehavioral score (p = 0.022)…Hydrogen appears to be promising as an effective, yet inexpensive way to reduce cerebral edema caused by surgical procedures. Hydrogen has the potential to improve clinical outcome, decrease hospital stay, and reduce overall cost to patients and the health care system.

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Oral ‘hydrogen water’ induces neuroprotective ghrelin secretion in mice“.
Akio Matsumoto et al.
The study demonstrated that supplementation with hydrogen-rich water resulted in an increased production of the hormone ghrelin (which is a hormone of interest in relation to sleep, appetite, memory, depression and even cancer due to its anti-inflammatory and anti-apoptotic potential).

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Drinking hydrogen water and intermittent hydrogen gas exposure, but not lactulose or continuous hydrogen gas exposure, prevent 6-hydorxydopamine-induced Parkinson’s disease in rats.
Ito, M., et al.
Hydrogen water; and intermittent exposure to 2% hydrogen gas prevented the development of 6-OHDA induced Parkinson’s Disease in a rats.

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Hydrogen-rich saline improves memory function in a rat model of amyloid-beta-induced Alzheimer’s disease by reduction of oxidative stress.
Li, J., et al.
“In conclusion, hydrogen-rich saline prevented Abeta-induced neuroinflammation and oxidative stress, which may contribute to the improvement of memory dysfunction in this rat model”.

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Hydrogen-rich saline reverses oxidative stress, cognitive impairment, and mortality in rats submitted to sepsis by cecal ligation and puncture.
Zhou, J., et al.,

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HYDROGEN Large review study spanning multiple fields, relating to various applications of hydrogen.

“Molecular hydrogen: a preventive and therapeutic medical gas for various diseases”

By Li Ge, Ming Yang et al. for:
Department of Histology and Embryology, School of Basic Medical Sciences, Taishan Medical University, Tai-an City, Shandong Province, China.
Department of Clinical Medicine, Taishan Medical University, Tai-an City, Shandong Province, China.
Key Laboratory of Atherosclerosis in Universities of Shandong, Taishan Medical University, Institute of Atherosclerosis, Taishan Medical University, Tai-an City, Shandong Province, China.
Department of medical immunology, School of Basic Medical Sciences, Taishan Medical University, Tai-an City, Shandong Province, China.nff

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Deuterium Depleted Water relating to brain function

Deuterium content of water increases depression susceptibility: the potential role of a serotonin-related mechanism
Tatyana Strekalova et al.
The study investigated the possible link between deuterium content of water and depression, both epidemiologically, and in a mouse model of chronic mild stress.
The study showed that deuterium depletion through the use of deuterium depleted water, decreased depression score, gave more restful sleep and sharpened wakefulness.

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Deuterium-depleted water has stimulating effects on long-term memory in rats
Cristian Mladin et al.
Deuterium-depleted water (DDW) is a water which has a 6-7-fold less concentration of the naturally occurring deuterium (20-25ppm vs. 150ppm). While administrated for a longer period, it may reduce the concentration of deuterium throughout the body, thus activating cellular mechanisms which are depending on protons (channels, pumps, enzyme proteins). The aim of the present work was to study, for the first time in our knowledge, the possible influence of deuterium-depleted water (DDW) chronic administration in normal Wistar rats, as compared to a control group which received distilled water, on spatial working memory and the locomotor activity (as studied through Y-maze) or both short-term and long-term spatial memory (assed in radial 8 arms-maze task).
…we could speculate that the administration of DDW may generate an improvement of the reference memory, as an index of long-term memory. Thus, we can reach the conclusion that the change between the deuterium/hydrogen balance may have important consequences for the mechanisms that govern long-term memory, as showed here especially in the behavioral parameters from the eight-arm radial maze task.

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Disclaimer:

The products of The Hydrogen Innovation Company Ltd. are not intended to diagnose, treat, cure or prevent any disease. No verbal or written communication from The Hydrogen Innovation Company Ltd., shall be interpreted as medical advice or contrary to the correct and proper use specified on the product label, or contrary to this disclaimer as a whole, which clearly outlines the intent of The Hydrogen Innovation Company Limited. The hydrogen water studies and deuterium depleted water studies on this page, were not conducted for The Hydrogen Innovation Company Ltd. (THIC) nor with any of its products (hydrogen-rich water, ddw water, hydrogen rich ddw water or any other of it’s products).