Anti-aging, Pro-Youth, Skin & Beauty Studies with Hydrogen Water



Hydrogen water intake via tube-feeding for patients with pressure ulcer and its reconstructive effects on normal human skin cells in vitro.
Li, Q., et al.
Twenty-two patients were retrospectively divided into an effective group (EG, n = 12) and a less effective group (LG, n = 10) according to the outcomes of endpoint evaluation and the healing criteria. PU hospitalized days in EG were significantly shorter than in LG (113.3 days vs. 155.4 days, p < 0.05), and the shortening rate was approximately 28.1%. Either in EG or in LG, the reducing changes (EG: 91.4%; LG: 48.6%) of wound size represented statistically significant difference versus before Hydrogen Water intake (p < 0.05, p < 0.001). The in vitro data demonstrate that intracellular ROS (Free radicals) as quantified by NBT assay was diminished by Hydrogen Water, but not by Regular Water.


“Hydrogen(H2) treatment for acute erythematous skin diseases. A report of 4 patients with safety data and a non-controlled feasibility study with H2 concentration measurement on two volunteers”.
Ono, H., et al.
Erythema of these 4 patients and associated symptoms improved significantly after the Hydrogen treatment and did not recur. Administration of H2 did not change physiological parameters and did not cause deterioration of the blood chemistry.


The Drinking Effect of Hydrogen Water on Atopic Dermatitis Induced by Dermatophagoides farinae Allergen in NC/Nga Mice.

Drinking hydrogen water suppressed the levels of inflammation-related mediators such as Th1, Th2, and pro-inflammatory cytokines which are number one players in the pathogenesis of human Atopic Dermatitis. In addition, this study provides a new insight of the relevance of certain cytokines in AD. Hydrogen Water represents a potentially alternative therapeutic and preventive treatment of Atopic Dermatitis.


“Hydrogen-rich Electrolyzed Warm Water Represses Wrinkle Formation Against UVA Ray Together With type-I Collagen Production and Oxidative-Stress Diminishment in Fibroblasts and Cell-Injury Prevention in Keratinocytes”
KATO, S., et al. (2012).


Hydrogen acts as a therapeutic antioxidant by selectively reducing cytotoxic oxygen radicals.
Cosmotology Clinic ”Beauty Institute”. Moscow, conclusion No.127 from 23.04.2003, No173 of 09.07.2003.
OHSAWA, I., ISHIKAWA, M., et al. (2007). Nat Med 13, 688-694.

Hydrogen enriched water improved mitochondria dysfunction.
Ito, M., et al.
Open-label trial and randomized, double-blind, placebo-controlled, crossover trial of hydrogen-enriched water for mitochondrial and inflammatory myopathies.



in Anti-aging pro-Youth

“Relation of antistress and geroprotective effects of deuterium depleted water in aging female rats.”
Oleg I. Kit , Alla I. Shikhliarova et al.
Drinking deuterium depleted water (DDW) for five weeks contributed to the overall correction of age-related disorders of the adaptive status, estrous cycle regulation and nonspecific resistance, as well as the appearance of visually distinct signs of rejuvenation of aging female rats (20–22 months).


“Anti-aging effects of deuterium depletion (with 90 ppm DDW) on Mn-induced toxicity in a C. elegans model” by Daiana Silva Ávala, Gábor Somlyai et al.
This study confirms other references studies that shows, that a link between aging and Deuterium is well established in that D2O concentrations exceeding the natural level resulted in numerous adverse effects:

  • Reduced the life-span of mice (Czajka and Finkel, 1960)
  • Increased viral mutation rates (Konrad, 1960)
  • Deuteration of synthetic estrogen hormones weakened its estrogenic properties (Thompson, 1963)
  • Deuterated enzymes exhibited conformational changes, affecting their active sites (Van Hook, 1971)
  • The skin became enriched in deuterium along a temporal aging axis (Griffiths, 1973)

The study goes on to discuss and conclude that Deuterium Depleted Light Water (DDW) did counteract the shortened life-span resulting from the study setup, but from that data alone and the short exposure time, the study could by itself not prove that DDW in general increased lifespan. The authors did however go on to take more of the known data into account, when they stated the following:

“…we cannot rule out that long term application of DDW will increase the life-span by reducing the number of gene alterations. Considering that the main pharmaceutical intervention with DDW is in cancer therapy (where conventional treatments cause strong side effects), future studies should further evaluate whether the application of DDW may be used to prevent or reduce the severity of the cytotoxic effect associated with conventional chemotherapies.”


“Physiological effects of drinking water enriched with 1H216O.” T.N. Burdeynaya et al.
P.K. Anokhin Institute of Normal Physiology of Russian Academy of Medical Science, Moscow, Russia.

Results of 28 days of drinking 1 liter of DDW revealed in every subject an improvement in health and reduced anxiety with improved psychological response.
The positive influence of drinking light DDW water on blood chemistries included a significant reduction of glycose, cholesterol, erythrocyte sedimentation rate, leukocyte counts and cortisol levels, while also revealed an increase in antioxidant capacities.

Volunteers who consumed 1 liter of light DDW water per day improved their hemodynamic parameters (i.e.: increased stroke volume and cardiac output, decreased total peripheral vascular resistance), which had a positive impact on overall physical performance and aerobic metabolism during an exercise.

HYDROGEN Large review study spanning multiple fields, relating to various applications of hydrogen.

“Molecular hydrogen: a preventive and therapeutic medical gas for various diseases”

By Li Ge, Ming Yang et al. for:
Department of Histology and Embryology, School of Basic Medical Sciences, Taishan Medical University, Tai-an City, Shandong Province, China.
Department of Clinical Medicine, Taishan Medical University, Tai-an City, Shandong Province, China.
Key Laboratory of Atherosclerosis in Universities of Shandong, Taishan Medical University, Institute of Atherosclerosis, Taishan Medical University, Tai-an City, Shandong Province, China.
Department of medical immunology, School of Basic Medical Sciences, Taishan Medical University, Tai-an City, Shandong Province, China.nff



The products of The Hydrogen Innovation Company Ltd. are not intended to diagnose, treat, cure or prevent any disease. No verbal or written communication from The Hydrogen Innovation Company Ltd., shall be interpreted as medical advice or contrary to the correct and proper use specified on the product label, or contrary to this disclaimer as a whole, which clearly outlines the intent of The Hydrogen Innovation Company Limited. The hydrogen water studies and deuterium depleted water studies on this page, were not conducted for The Hydrogen Innovation Company Ltd. (THIC) nor with any of its products (hydrogen-rich water, ddw water, hydrogen rich ddw water or any other of it’s products).